Ontology highlight
ABSTRACT:
SUBMITTER: Rojas C
PROVIDER: S-EPMC6286365 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Rojas Camilo C Barnaeva Elena E Thomas Ajit G AG Hu Xin X Southall Noel N Marugan Juan J Chaudhuri Amrita Datta AD Yoo Seung-Wan SW Hin Niyada N Stepanek Ondrej O Wu Ying Y Zimmermann Sarah C SC Gadiano Alexandra G AG Tsukamoto Takashi T Rais Rana R Haughey Norman N Ferrer Marc M Slusher Barbara S BS
Scientific reports 20181207 1
Brain injury and inflammation induces a local release of extracellular vesicles (EVs) from astrocytes carrying proteins, RNAs, and microRNAs into the circulation. When these vesicles reach the liver, they stimulate the secretion of cytokines that mobilize peripheral immune cell infiltration into the brain, which can cause secondary tissue damage and impair recovery. Recent studies suggest that suppression of EV biosynthesis through neutral sphingomyelinase 2 (nSMase2) inhibition may represent a ...[more]