Ontology highlight
ABSTRACT:
SUBMITTER: Bagratuni T
PROVIDER: S-EPMC6286389 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Bagratuni Tina T Ntanasis-Stathopoulos Ioannis I Gavriatopoulou Maria M Mavrianou-Koutsoukou Nefeli N Liacos Christine C Patseas Dimitrios D Kanellias Nikolaos N Migkou Magdalini M Ziogas Dimitrios C DC Eleutherakis-Papaiakovou Evangelos E Roussou Maria M Fotiou Despina D Terpos Evangelos E Kastritis Efstathios E Dimopoulos Meletios A MA
Leukemia 20180719 12
Liquid biopsyis being integrated into cancer diagnostics with profound therapeutic implications. However, its role in Waldenström's Macroglobulinemia (WM) and IgM monoclonal gammopathies is still unclear. In this study, we evaluated the role of peripheral blood (PB) cell-free DNA (cfDNA) in characterizing the mutational status of MYD88 and CXCR4 of patients with IgM monoclonal gammopathies. Paired bone marrow (BM) tumor DNA (tDNA) and PB cfDNA samples from 98 patients (9 MGUS, 45 with WM in remi ...[more]