Dataset Information

Pregnancy-associated cancers and birth outcomes in children: a Danish and Swedish population-based register study.

ABSTRACT:

Objectives

This study aims to estimate the association between pregnancy-associated maternal cancers, diagnosed both prenatally and postnatally, and birth outcomes.

Design

Population-based register study.

Setting

National registers of Denmark and Sweden.

Participants

A total of 5 523 365 children born in Denmark (1977-2008) and Sweden (1973-2006).Primary and secondary outcome measures: gestational age, birth weight, size for gestational age, Apgar score, caesarean section and sex were the outcomes of interest. ORs and relative risk ratios (RRR) with 95% CIs were estimated using logistic regression and multinomial logistic regression, respectively.

Results

In this study, 2% of children were born to mothers with a diagnosis of cancer. Children whose mothers received a prenatal cancer diagnosis had higher risk of being born preterm (RRR: 1.77, 95%?CI 1.64 to 1.90); low birth weight (RRR 1.84, 95%?CI 1.69 to 2.01); low Apgar score (OR 1.36, 95%?CI 1.20 to 1.56); and by caesarean section (OR: 1.69, 95%?CI 1.59 to 1.80). Associations moved towards the null for analyses using postnatal diagnoses, but preterm birth (RRR: 1.13, 95%?CI 1.09 to 1.17) and low birth weight (RRR: 1.14, 95%?CI 1.09 to 1.18) remained statistically significant, while risk of caesarean section became so (OR: 0.95, 95%?CI 0.91 to 0.98). Additionally, statistical significance was reached for large for gestational age (RRR: 1.06, 95%?CI 1.01 to 1.11), high birth weight (RRR: 1.04, 95%?CI 1.01 to 1.06) and caesarean section (OR: 0.95, 95%?CI 0.91 to 0.98).

Conclusions

Results suggest an association between pregnancy-associated cancers and adverse birth outcomes in the offspring. While this is strongest for prenatally diagnosed cancers, some smaller associations exist for postnatally diagnosed cancers, indicating that cancer itself could affect fetal development, or that cancer and adverse birth outcomes share risk factors. Future studies on maternal cancer during pregnancy should consider including some postnatal years in their exposure window.

SUBMITTER: Momen NC

PROVIDER: S-EPMC6286483 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Pregnancy-associated cancers and birth outcomes in children: a Danish and Swedish population-based register study.

Momen Natalie C NC Arendt Linn Håkonsen LH Ernst Andreas A Olsen Jørn J Li Jiong J Gissler Mika M Ramlau-Hansen Cecilia H CH

BMJ open 20181204 12

<h4>Objectives</h4>This study aims to estimate the association between pregnancy-associated maternal cancers, diagnosed both prenatally and postnatally, and birth outcomes.<h4>Design</h4>Population-based register study.<h4>Setting</h4>National registers of Denmark and Sweden.<h4>Participants</h4>A total of 5 523 365 children born in Denmark (1977-2008) and Sweden (1973-2006).Primary and secondary outcome measures: gestational age, birth weight, size for gestational age, Apgar score, caesarean se ...[more]

PMID: 30518582

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Dataset Information

Pregnancy-associated cancers and birth outcomes in children: a Danish and Swedish population-based register study.

Objectives

Design

Setting

Participants

Results

Conclusions

Publications

Pregnancy-associated cancers and birth outcomes in children: a Danish and Swedish population-based register study.

Similar Datasets

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