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An ultra-stable redox-controlled self-assembling polypeptide nanotube for targeted imaging and therapy in cancer.

ABSTRACT: We introduce a self-assembling polypeptide-based nanotube system having the ability to specifically target cancer cells. The nanotubes target the cancer cell surface through integrin engagement with the help of multiple RGD units present along their surface. While the nanotubes are non-toxic towards cells in general, they can be loaded with suitable drugs to be released in a sustained manner in cancer cells. In addition, the nanotubes can be utilized for cellular imaging using any covalently tagged fluorescent dye. They are stable over a wide range of temperature due to intermolecular disulphide bonds formed during the self-assembly process. At the same time, presence of disulphide bonds provides a redox molecular switch for their degradation. Taken together this system provides a unique avenue for multimodal formulation in cancer therapy.

SUBMITTER: Asampille G

PROVIDER: S-EPMC6286583 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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An ultra-stable redox-controlled self-assembling polypeptide nanotube for targeted imaging and therapy in cancer.

Asampille Gitanjali G Verma Brijesh Kumar BK Swain Monalisa M Shettar Abhijith A Rosenzweig Steven A SA Kondaiah Paturu P Atreya Hanudatta S HS

Journal of nanobiotechnology 20181208 1

We introduce a self-assembling polypeptide-based nanotube system having the ability to specifically target cancer cells. The nanotubes target the cancer cell surface through integrin engagement with the help of multiple RGD units present along their surface. While the nanotubes are non-toxic towards cells in general, they can be loaded with suitable drugs to be released in a sustained manner in cancer cells. In addition, the nanotubes can be utilized for cellular imaging using any covalently tag ...[more]

PMID: 30526620

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