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Observational study of the status of coronary risk biomarkers among Negritos with metabolic syndrome in the east coast of Malaysia.

ABSTRACT: OBJECTIVES:To determine the prevalence of metabolic syndrome (MS), ascertain the status of coronary risk biomarkers and establish the independent predictors of these biomarkers among the Negritos. SETTINGS:Health screening programme conducted in three inland settlements in the east coast of Malaysia and Peninsular Malaysia. SUBJECTS:150 Negritos who were still living in three inland settlements in the east coast of Malaysia and 1227 Malays in Peninsular Malaysia. These subjects were then categorised into MS and non-MS groups based on the International Diabetes Federation (IDF) consensus worldwide definition of MS and were recruited between 2010 and 2015. The subjects were randomly selected and on a voluntary basis. PRIMARY AND SECONDARY OUTCOME MEASURES:This study was a cross-sectional study. Serum samples were collected for analysis of inflammatory (hsCRP), endothelial activation (sICAM-1) and prothrombogenesis [lp(a)] biomarkers. RESULTS:MS was significantly higher among the Malays compared with Negritos (27.7%vs12.0%). Among the Malays, MS subjects had higher hsCRP (p=0.01) and sICAM-1 (p<0.05) than their non-MS counterpart. There were no significant differences in all the biomarkers between MS and the non-MS Negritos. However, when compared between ethnicity, all biomarkers were higher in Negritos compared with Malays (p<0.001). Binary logistic regression analysis affirmed that Negritos were an independent predictor for Lp(a) concentration (p<0.001). CONCLUSIONS:This study suggests that there may possibly be a genetic influence other than lifestyle, which could explain the lack of difference in biomarkers concentration between MS and non-MS Negritos and for Negritos predicting Lp(a).

SUBMITTER: Mokhsin A

PROVIDER: S-EPMC6286619 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Observational study of the status of coronary risk biomarkers among Negritos with metabolic syndrome in the east coast of Malaysia.

Mokhsin Atiqah A Mokhtar Siti Shuhada SS Mohd Ismail Aletza A M Nor Fadzilah F Shaari Syahrul Azlin SA Nawawi Hapizah H Yusoff Khalid K Abdul Rahman Thuhairah T Hoh Boon Peng BP

BMJ open 20181204 12

<h4>Objectives</h4>To determine the prevalence of metabolic syndrome (MS), ascertain the status of coronary risk biomarkers and establish the independent predictors of these biomarkers among the Negritos.<h4>Settings</h4>Health screening programme conducted in three inland settlements in the east coast of Malaysia and Peninsular Malaysia.<h4>Subjects</h4>150 Negritos who were still living in three inland settlements in the east coast of Malaysia and 1227 Malays in Peninsular Malaysia. These subj ...[more]

PMID: 30518581

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Project description:BackgroundPoor waste disposal practices hamper the progress towards an integrated solid waste management in households. Knowledge of current practices and perception of household solid waste management is necessary for accurate decision making in the move towards a more sustainable approach. This study investigates the household waste practices and perceptions about waste management in Panji, one of the sub-districts in Kota Bharu, Kelantan, Malaysia.MethodsA stratified random sampling technique using a cross-sectional survey questionnaire was used to collect data. A total of 338 households were interviewed in the survey and data were analyzed using SPSS. Chi-square goodness of fit test was used to determine the relationships between categorical variables, whereas Chi-square bivariate correlation test was performed to observe the correlation between the perceptions of waste segregation with socio-demographic background of the respondents. The correlation between perception of respondents with the locality, house type and waste type were also conducted. Principal component analysis was used to identify grouping of variables and to establish which factors were interrelated in any given construct.ResultsThe results of the study revealed that 74.3 % of households disposed of food debris as waste and 18.3% disposed of plastic materials as waste. The study also showed that 50.3% of the households segregate their waste while 49.7% did not. About 95.9% of the respondents were aware that improper waste management leads to disease; such as diarrhea and malaria. There were associations between locality, age and house type with waste segregation practices among respondents (Chi-square test, p<0.05). Associations were also found between locality with the perception of improper waste management which lead to disease (Chi-square test, p<0.05). Principal Component Analysis showed that 17.94% of the variance has high positive loading (positive relationship) with age, marital status and, type of house.ConclusionThis study highlights the importance to design waste separation programs that suit the needs of targeted population as a boost towards sustainable solid waste management practices.

Dataset Information

Observational study of the status of coronary risk biomarkers among Negritos with metabolic syndrome in the east coast of Malaysia.

Publications

Observational study of the status of coronary risk biomarkers among Negritos with metabolic syndrome in the east coast of Malaysia.

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