Structural and Epitope Analysis (T- and B-Cell Epitopes) of Hepatitis C Virus (HCV) Glycoproteins: An in silico Approach.

ABSTRACT:

Background

Chronic infection with Hepatitis C Virus (HCV) poses a major risk for liver disease like cirrhosis, liver failure and hepatocellular carcinoma. In terms of percentage, the prevalence of HCV in India was found to be low to moderate (1-1.5%), but in terms of sheer numbers, India has a significant number of global HCV patients. Presently, HCV can be treated with direct acting-antibody drugs but there is no prophylactic or therapeutic vaccine available against it. In HCV infection, T- and B-cell immunity is important for clearing the virus. In the present study immunoinformatics was used to identify potent vaccine target for HCV vaccine development.

Methods

Sequence of HCV was retrieved from NCBI and their structural analysis was done by using Protpram, PSIPRED, iTASS

SUBMITTER: Kumar A 

PROVIDER: S-EPMC6286880 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature