Ontology highlight
ABSTRACT:
SUBMITTER: Karamichali E
PROVIDER: S-EPMC6287115 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Karamichali Eirini E Chihab Hajar H Kakkanas Athanassios A Marchio Agnes A Karamitros Timokratis T Pogka Vasiliki V Varaklioti Agoritsa A Kalliaropoulos Antonis A Martinez-Gonzales Beatrice B Foka Pelagia P Koskinas Ioannis I Mentis Andreas A Benjelloun Soumaya S Pineau Pascal P Georgopoulou Urania U
Frontiers in microbiology 20181203
Defective interfering (DI) RNAs have been detected in several human viruses. HCV in-frame deletions mutants (IFDMs), missing mainly the envelope proteins, have been found in patient sera and liver tissues. IFDMs replicate independently and can be <i>trans</i>-packaged into infectious virions in the presence of full length viral genome. So far, their biological role is unclear. In this study, we have isolated and cloned IFDMs from sera samples and liver tissues of patients infected with HCV genot ...[more]