Developmental and epigenetic regulation of the human TLR3 gene.
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ABSTRACT:
SUBMITTER: Porras A
PROVIDER: S-EPMC6287275 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
Developmental and epigenetic regulation of the human TLR3 gene.
Porrás Analia A Kozar Sarah S Russanova Valya V Salpea Paraskevi P Hirai Tazuko T Sammons Nicholas N Mittal Pooja P Kim Ji Young JY Ozato Keiko K Romero Roberto R Howard Bruce H BH
Molecular immunology 20080819 1
The receptor encoded by the human TLR3 gene recognizes double-strand RNAs (dsRNAs) associated with viral infection. TLR3 expression is strongly activated upon differentiation of monocytes to dendritic cells, and can be further stimulated by the dsRNA analog polyinosine:polycytosine (PI:C). We report evidence for developmental regulation of the TLR3 gene. In dendritic cells derived from cord blood, both differentiation- and PI:C-associated TLR3 transcriptional activation are impaired as compared ...[more]
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