Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity.
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ABSTRACT:
SUBMITTER: Bagger SO
PROVIDER: S-EPMC6287350 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity.
Bagger Sofie Otzen SO Hopkinson Branden Michael BM Pandey Deo Prakash DP Bak Mads M Brydholm Andreas Vincent AV Villadsen Rene R Helin Kristian K Rønnov-Jessen Lone L Petersen Ole William OW Kim Jiyoung J
Molecular cancer 20181210 1
Tumorigenesis is increasingly considered to rely on subclones of cells poised to undergo an epithelial to mesenchymal transition (EMT) program. We and others have provided evidence, however, that the tumorigenesis of human breast cancer is not always restricted to typical EMT cells but is also somewhat paradoxically conveyed by subclones of apparently differentiated, non-EMT cells. Here we characterize such non-EMT-like and EMT-like subclones. Through a loss-of-function screen we found that a me ...[more]
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