Unknown

Dataset Information

0

Animal models for studying the etiology and treatment of low back pain.

ABSTRACT: Chronic low back pain is a major cause of disability and health care costs. Effective treatments are inadequate for many patients. Animal models are essential to further understanding of the pain mechanism and testing potential therapies. Currently, a number of preclinical models have been developed attempting to mimic aspects of clinical conditions that contribute to low back pain (LBP). This review focused on describing these animal models and the main behavioral tests for assessing pain in each model. Animal models of LBP can be divided into the following five categories: Discogenic LBP, radicular back pain, facet joint osteoarthritis back pain, muscle-induced LBP, and spontaneous occurring LBP models. These models are important not only for enhancing our knowledge of how LBP is generated, but also for the development of novel therapeutic regimens to treat LBP in patients. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1305-1312, 2018.

SUBMITTER: Shi C 

PROVIDER: S-EPMC6287742 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Animal models for studying the etiology and treatment of low back pain.

Shi Changgui C   Qiu Sujun S   Riester Scott M SM   Das Vaskar V   Zhu Bingqian B   Wallace Atiyayein A AA   van Wijnen Andre J AJ   Mwale Fackson F   Iatridis James C JC   Sakai Daisuke D   Votta-Velis Gina G   Yuan Wen W   Im Hee-Jeong HJ  

Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20180314 5

Chronic low back pain is a major cause of disability and health care costs. Effective treatments are inadequate for many patients. Animal models are essential to further understanding of the pain mechanism and testing potential therapies. Currently, a number of preclinical models have been developed attempting to mimic aspects of clinical conditions that contribute to low back pain (LBP). This review focused on describing these animal models and the main behavioral tests for assessing pain in ea  ...[more]

Similar Datasets

Transcriptomics Single cell RNA-seq data for studying human intervertebral discs and the mechanism of discogenic low back pain
2023-01-09 | GSE222182 | GEO
Unknown Yoga treatment for chronic non-specific low back pain.
| S-EPMC5294833 | biostudies-literature
Unknown Dorsal root ganglion compression as an animal model of sciatica and low back pain.
| S-EPMC5561928 | biostudies-other
Unknown Non-Specific Low Back Pain.
| S-EPMC5769319 | biostudies-other
Unknown Treatment of chronic low back pain - new approaches on the horizon.
| S-EPMC5436786 | biostudies-literature
Unknown Brain functional connectivity changes by low back extension pain model in low back pain patients.
| S-EPMC7263586 | biostudies-literature
Unknown Pilates for low back pain.
| S-EPMC8078578 | biostudies-literature
Unknown Treatment of Low Back Pain With Opioids and Nonpharmacologic Treatment Modalities for Army Veterans.
| S-EPMC6143345 | biostudies-literature
Unknown Association of low back load with low back pain during static standing.
| S-EPMC6298701 | biostudies-literature
Unknown Common Clinical Practice for Low Back Pain Treatment: A Modified Delphi Study.
| S-EPMC8119580 | biostudies-literature