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Ultrasound-based formation of nano-Pickering emulsions investigated via in-situ SAXS.

ABSTRACT: Sonication is one of the most commonly used methods to synthesize Pickering emulsions. Yet, the process of emulsion sonication is rarely characterized in detail and acoustic conditions are largely determined by experimenter's personal experience. In this study, the role of sonication in the formation of Pickering emulsions from amphiphilic gold nanoparticles was investigated using a new sample environment combining ultrasound delivery with ultra-small-angle X-ray scattering (USAXS) measurements. The detection of acoustic cavitation and the simultaneous analysis of structural data via USAXS demonstrated direct correlation between Pickering emulsion formation and cavitation events. There was no evidence of spontaneous adsorption of particles onto the oil-water interface without ultrasound, which suggests the presence of a stabilizing force. Acoustically detected cavitation events could originate in the bulk solvent and/or inside the emulsion droplets. These events helped overcome energy barriers to induce particle adsorption.

SUBMITTER: Lee YT

PROVIDER: S-EPMC6287929 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Ultrasound-based formation of nano-Pickering emulsions investigated via in-situ SAXS.

Lee Yi-Ting YT Li David S DS Ilavsky Jan J Kuzmenko Ivan I Jeng Geng-Shi GS O'Donnell Matthew M Pozzo Lilo D LD

Journal of colloid and interface science 20181019

Sonication is one of the most commonly used methods to synthesize Pickering emulsions. Yet, the process of emulsion sonication is rarely characterized in detail and acoustic conditions are largely determined by experimenter's personal experience. In this study, the role of sonication in the formation of Pickering emulsions from amphiphilic gold nanoparticles was investigated using a new sample environment combining ultrasound delivery with ultra-small-angle X-ray scattering (USAXS) measurements. ...[more]

PMID: 30380428

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Project description:Periodontitis (PD) as a chronic inflammatory disease instigated by periodontal pathogenic bacteria and mediated by the host immune response, resulting in the destruction of supporting periodontal tissue and tooth loss in adults. Constructing an injectable delivery system that allows for sustained drug release within periodontal pockets to continuously eliminate pathogenic bacteria, reduce periodontal inflammation, and promote periodontal tissue regeneration is an effective strategy for periodontitis treatment. Here, we explore the therapeutic potential and underlying mechanisms of curcumin-loaded Pickering emulsion (PE-CUR) in periodontitis treatment. The Pickering emulsion formulation offers an effective delivery system, enhancing curcumin's bioavailability and therapeutic efficacy. In vitro studies, we demonstrate that the PE-CUR exhibit excellent biocompatibility and anti-inflammatory property by elimination of reactive oxygen species (ROS). In addition, PE-CUR significantly eliminate key periodontal pathogens, including Porphyromonas gingivalis (P. gingivalis) and Staphylococcus aureus (S. aureus). In a rat model of periodontitis, PE-CUR significantly attenuates periodontal tissue inflammation and alveolar bone loss, indicating a protective effect against periodontal tissue destruction. Mechanistically, PE-CUR promotes the expression of anti-inflammatory factors and inhibits the release of pro-inflammatory factors by regulating macrophage polarization from M1 to M2 and modulating the MAPK and PI3K-AKT signaling pathway. Furthermore, PE-CUR decreases the formation of osteoclasts as well as stimulates the activation and differentiation of osteoblasts successively, thereby ameliorating the periodontal inflammation and promoting the alveolar bone regeneration. Overall, our findings elucidate the therapeutic mechanisms of PE-CUR in periodontitis, suggesting its potential as a promising treatment strategy warranting further clinical investigation.

Dataset Information

Ultrasound-based formation of nano-Pickering emulsions investigated via in-situ SAXS.

Publications

Ultrasound-based formation of nano-Pickering emulsions investigated via in-situ SAXS.

Similar Datasets

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