Ontology highlight
ABSTRACT:
SUBMITTER: Kotlajich MV
PROVIDER: S-EPMC6287932 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Kotlajich Matthew V MV Xia Jun J Zhai Yin Y Lin Hsin-Yu HY Bradley Catherine C CC Shen Xi X Mei Qian Q Wang Anthony Z AZ Lynn Erica J EJ Shee Chandan C Chen Li-Tzu LT Li Lei L Miller Kyle M KM Herman Christophe C Hastings P J PJ Rosenberg Susan M SM
DNA repair 20180914
The N protein of phage Mu was indicated from studies in Escherichia coli to hold linear Mu chromosomes in a circular conformation by non-covalent association, and thus suggested potentially to bind DNA double-stranded ends. Because of its role in association with linear Mu DNA, we tested whether fluorescent-protein fusions to N might provide a useful tool for labeling DNA damage including double-strand break (DSB) ends in single cells. We compared N-GFP with a biochemically well documented DSB-e ...[more]