Ontology highlight
ABSTRACT:
SUBMITTER: Holding AN
PROVIDER: S-EPMC6287946 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Holding Andrew N AN Cullen Amy E AE Markowetz Florian F
eLife 20181120
Estrogen Receptor-alpha (ER) drives 75% of breast cancers. Stimulation of the ER by estra-2-diol forms a transcriptionally-active chromatin-bound complex. Previous studies reported that ER binding follows a cyclical pattern. However, most studies have been limited to individual ER target genes and without replicates. Thus, the robustness and generality of ER cycling are not well understood. We present a comprehensive genome-wide analysis of the ER after activation, based on 6 replicates at 10 ti ...[more]