Identifying the period of greatest blood loss after lower limb arthroplasty.

ABSTRACT:

Background

The use of tranexamic acid (TXA) in total hip replacement (THR) typically reduces blood loss by approximately 400 mL, and typical total blood loss is still approximately 1 L. A barrier to harnessing the full potential of TXA is disagreement on the optimum timing of administration. To address this, we aimed to identify the period of greatest blood loss.

Methods

We analyzed the perioperative data of 870 patients who had undergone THR, total knee replacement, or unicompartmental knee replacement just before the introduction of TXA to our unit. Total blood loss was calculated on postoperative day (POD) 1 and POD2 using an equation based on change in hematocrit.

Results

Average total blood loss at POD2 was 1505, 1322, and 611 mL for THR, total knee replacement,

SUBMITTER: Magill P 

PROVIDER: S-EPMC6288045 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature