Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Gomez A
PROVIDER: S-EPMC6288085 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Perez-Gomez Anabel A Carretero Maria M Weber Natalie N Peterka Veronika V To Alan A Titova Viktoriya V Solis Gregory G Osborn Olivia O Petrascheck Michael M
Nature communications 20181210 1
Antipsychotic (AP) drugs are used to treat psychiatric disorders but are associated with significant weight gain and metabolic disease. Increased food intake (hyperphagia) appears to be a driving force by which APs induce weight gain but the mechanisms are poorly understood. Here we report that administration of APs to C. elegans induces hyperphagia by a mechanism that is genetically distinct from basal food intake. We exploit this finding to screen for adjuvant drugs that suppress AP-induced hy ...[more]