Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability.
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ABSTRACT:
SUBMITTER: Morgan MD
PROVIDER: S-EPMC6288091 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
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Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability.
Morgan Michael D MD Pairo-Castineira Erola E Rawlik Konrad K Canela-Xandri Oriol O Rees Jonathan J Sims David D Tenesa Albert A Jackson Ian J IJ
Nature communications 20181210 1
Natural hair colour within European populations is a complex genetic trait. Previous work has established that MC1R variants are the principal genetic cause of red hair colour, but with variable penetrance. Here, we have extensively mapped the genes responsible for hair colour in the white, British ancestry, participants in UK Biobank. MC1R only explains 73% of the SNP heritability for red hair in UK Biobank, and in fact most individuals with two MC1R variants have blonde or light brown hair. We ...[more]
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