From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin?
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ABSTRACT:
SUBMITTER: Bonnet AL
PROVIDER: S-EPMC6288187 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin?
Bonnet Anne-Laure AL Chaussain Catherine C Broutin Isabelle I Rochefort Gaël Y GY Schrewe Heinrich H Gaucher Céline C
Frontiers in medicine 20181204
First described in 1988, vasorin (VASN) is a transmembrane glycoprotein expressed during early mouse development, and with a less extent, in various organs and tissues (e.g., kidney, aorta, and brain) postnatally. <i>Vasn</i> KO mice die after 3 weeks of life from unknown cause(s). No human disease has been associated with variants of this gene so far, but VASN seems to be a potential biomarker for nephropathies and tumorigenesis. Its interactions with the TGF-β and Notch1 pathways offer the mos ...[more]
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