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From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin?


ABSTRACT: First described in 1988, vasorin (VASN) is a transmembrane glycoprotein expressed during early mouse development, and with a less extent, in various organs and tissues (e.g., kidney, aorta, and brain) postnatally. Vasn KO mice die after 3 weeks of life from unknown cause(s). No human disease has been associated with variants of this gene so far, but VASN seems to be a potential biomarker for nephropathies and tumorigenesis. Its interactions with the TGF-? and Notch1 pathways offer the most serious assumptions regarding VASN functions. In this review, we will describe current knowledge about this glycoprotein and discuss its implication in various organ pathophysiology.

SUBMITTER: Bonnet AL 

PROVIDER: S-EPMC6288187 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin?

Bonnet Anne-Laure AL   Chaussain Catherine C   Broutin Isabelle I   Rochefort Gaël Y GY   Schrewe Heinrich H   Gaucher Céline C  

Frontiers in medicine 20181204


First described in 1988, vasorin (VASN) is a transmembrane glycoprotein expressed during early mouse development, and with a less extent, in various organs and tissues (e.g., kidney, aorta, and brain) postnatally. <i>Vasn</i> KO mice die after 3 weeks of life from unknown cause(s). No human disease has been associated with variants of this gene so far, but VASN seems to be a potential biomarker for nephropathies and tumorigenesis. Its interactions with the TGF-β and Notch1 pathways offer the mos  ...[more]

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