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Tofacitinib for refractory uveitis and scleritis.


ABSTRACT: Purpose:To report the successful use of tofacitinib in the treatment of refractory uveitis and scleritis. Observations:Two patients, one with scleritis and another with anterior and intermediate uveitis, presented with refractory disease after failure of multiple steroid-sparing therapies. Treatment with tofacitinib led to durable resolution of uveitis and scleritis. Conclusions and importance:Tofacitinib is a potential novel treatment option for refractory, noninfectious inflammatory eye disease.

SUBMITTER: Paley MA 

PROVIDER: S-EPMC6288302 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Tofacitinib for refractory uveitis and scleritis.

Paley Michael A MA   Karacal Humeyra H   Rao P Kumar PK   Margolis Todd P TP   Miner Jonathan J JJ  

American journal of ophthalmology case reports 20181204


<h4>Purpose</h4>To report the successful use of tofacitinib in the treatment of refractory uveitis and scleritis.<h4>Observations</h4>Two patients, one with scleritis and another with anterior and intermediate uveitis, presented with refractory disease after failure of multiple steroid-sparing therapies. Treatment with tofacitinib led to durable resolution of uveitis and scleritis.<h4>Conclusions and importance</h4>Tofacitinib is a potential novel treatment option for refractory, noninfectious i  ...[more]

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