Ontology highlight
ABSTRACT:
SUBMITTER: Muller T
PROVIDER: S-EPMC6288480 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Physiological reports 20181201 23
The bioactive peptides of the apelinergic system and its receptor APJ have been shown to play a protective role in experimental cardiovascular and diabetic kidney disease (DKD). Mechanisms of this renoprotective effect remain to be elucidated. In this study, we examined the localization of APJ within the normal kidney and its kidney expression in the db/db model of DKD. The effect of hyperglycemia and angiotensin II on APJ was examined in cultured podocytes. In the glomerulus, APJ colocalized wi ...[more]