Xenopus Hybrids Provide Insight Into Cell and Organism Size Control.

ABSTRACT: Determining how size is controlled is a fundamental question in biology that is poorly understood at the organismal, cellular, and subcellular levels. The Xenopus species, X. laevis and X. tropicalis differ in size at all three of these levels. Despite these differences, fertilization of X. laevis eggs with X. tropicalis sperm gives rise to viable hybrid animals that are intermediate in size. We observed that although hybrid and X. laevis embryogenesis initiates from the same sized zygote and proceeds synchronously through development, hybrid animals were smaller by the tailbud stage, and a change in the ratio of nuclear size to cell size was observed shortly after zygotic genome activation (ZGA), suggesting that differential gene expression contri

SUBMITTER: Gibeaux R 

PROVIDER: S-EPMC6288844 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature