Ontology highlight
ABSTRACT:
SUBMITTER: Wild T
PROVIDER: S-EPMC6289045 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Wild Thomas T Budzowska Magda M Hellmuth Susanne S Eibes Susana S Karemore Gopal G Barisic Marin M Stemmann Olaf O Choudhary Chunaram C
Cell reports 20181101 9
The multisubunit ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome) is essential for mitosis by promoting timely degradation of cyclin B1. APC/C is tightly regulated by the spindle assembly checkpoint (SAC), which involves MPS1 and MAD2-dependent temporal inhibition of APC/C. We analyzed the contribution of the APC/C subunits APC7 and APC16 to APC/C composition and function in human cells. APC16 is required for APC7 assembly into APC/C, whereas APC16 assembles independently of APC7. A ...[more]