Unknown

Dataset Information

0

IgG3 regulates tissue-like memory B cells in HIV-infected individuals.


ABSTRACT: Immunoglobulin G3 (IgG3) has an uncertain role in the response to infection with and vaccination against human immunodeficiency virus (HIV). Here we describe a regulatory role for IgG3 in dampening the immune system-activating effects of chronic HIV viremia on B cells. Secreted IgG3 was bound to IgM-expressing B cells in vivo in HIV-infected chronically viremic individuals but not in early-viremic or aviremic individuals. Tissue-like memory (TLM) B cells, a population expanded by persistent HIV viremia, bound large amounts of IgG3. IgG3 induced clustering of B cell antigen receptors (BCRs) on the IgM+ B cells, which was mediated by direct interactions between soluble IgG3 and membrane IgM of the BCR (IgM-BCR). The inhibitory IgG receptor CD32b (Fc?RIIb), complement component C1q and inflammatory biomarker CRP contributed to the binding of secreted IgG3 onto IgM-expressing B cells of HIV-infected individuals. Notably, IgG3-bound TLM B cells were refractory to IgM-BCR stimulation, thus demonstrating that IgG3 can regulate B cells during chronic activation of the immune system.

SUBMITTER: Kardava L 

PROVIDER: S-EPMC6289069 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications


Immunoglobulin G3 (IgG3) has an uncertain role in the response to infection with and vaccination against human immunodeficiency virus (HIV). Here we describe a regulatory role for IgG3 in dampening the immune system-activating effects of chronic HIV viremia on B cells. Secreted IgG3 was bound to IgM-expressing B cells in vivo in HIV-infected chronically viremic individuals but not in early-viremic or aviremic individuals. Tissue-like memory (TLM) B cells, a population expanded by persistent HIV  ...[more]

Similar Datasets

| S-EPMC7038621 | biostudies-literature
| S-EPMC4889535 | biostudies-other
| S-EPMC6629130 | biostudies-literature
2020-05-15 | GSE126230 | GEO
2014-06-24 | GSE56499 | GEO
2014-06-24 | E-GEOD-56499 | biostudies-arrayexpress
| S-EPMC3348904 | biostudies-literature
| S-EPMC4071400 | biostudies-literature
| PRJNA521359 | ENA
| S-EPMC5035742 | biostudies-literature