Ontology highlight
ABSTRACT:
SUBMITTER: Kardava L
PROVIDER: S-EPMC6289069 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Kardava Lela L Sohn Haewon H Youn Christine C Austin James W JW Wang Wei W Buckner Clarisa M CM Justement J Shawn JS Melson Valerie A VA Roth Gwynne E GE Hand Marissa A MA Gittens Kathleen R KR Kwan Richard W RW Sneller Michael C MC Li Yuxing Y Chun Tae-Wook TW Sun Peter D PD Pierce Susan K SK Moir Susan S
Nature immunology 20180813 9
Immunoglobulin G3 (IgG3) has an uncertain role in the response to infection with and vaccination against human immunodeficiency virus (HIV). Here we describe a regulatory role for IgG3 in dampening the immune system-activating effects of chronic HIV viremia on B cells. Secreted IgG3 was bound to IgM-expressing B cells in vivo in HIV-infected chronically viremic individuals but not in early-viremic or aviremic individuals. Tissue-like memory (TLM) B cells, a population expanded by persistent HIV ...[more]