Ontology highlight
ABSTRACT:
SUBMITTER: Yao Y
PROVIDER: S-EPMC6289071 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Yao Yao Y Yu Haixia H Liu Yaru Y Xu Qingqing Q Li Xiaofeng X Meng Xiaoming X Huang Cheng C Li Jun J
Frontiers in pharmacology 20181204
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease and its pathogenesis remains unclear. Fibroblast-like synoviocytes (FLSs) play an important role in the pathogenesis of RA. Proline-serine-threonine phosphatase interacting protein 2 (PSTPIP2) is an adaptor protein, which is associated with auto-inflammatory disease. In this study, we selected adjuvant-induced arthritis (AIA) as animal model to study the role of PSTPIP2 in FLSs. We found that the expression of PSTPIP2 was sig ...[more]