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Can a Charged Surfactant Unfold an Uncharged Protein?


ABSTRACT: Does sodium dodecyl sulfate (SDS) denature proteins through electrostatic SDS-protein interactions? We show that a protein completely lacking charged side chains is unfolded by SDS in a manner similar to charged proteins, revealing that formal protein charges are not required for SDS-induced protein unfolding or binding.

SUBMITTER: Hojgaard C 

PROVIDER: S-EPMC6289093 | biostudies-literature |

REPOSITORIES: biostudies-literature

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