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Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit.


ABSTRACT: In the intensive care unit (ICU) setting, where highly variable and insufficient drug efficacies, as well as frequent and unpredictable adverse drug reactions (ADRs) occur, pharmacogenomics (PGx) offers an opportunity to improve health outcomes. However, PGx has not been fully evaluated in the ICU, partly due to lack of knowledge of how genetic markers may affect drug therapy. To fill in this gap, we conducted a review to summarize the PGx information for the medications commonly encountered in the ICU.

SUBMITTER: Zhou S 

PROVIDER: S-EPMC6289166 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit.

Zhou Shuqin S   Skaar Debra J DJ   Jacobson Pamala A PA   Huang R Stephanie RS  

Frontiers in pharmacology 20181204


In the intensive care unit (ICU) setting, where highly variable and insufficient drug efficacies, as well as frequent and unpredictable adverse drug reactions (ADRs) occur, pharmacogenomics (PGx) offers an opportunity to improve health outcomes. However, PGx has not been fully evaluated in the ICU, partly due to lack of knowledge of how genetic markers may affect drug therapy. To fill in this gap, we conducted a review to summarize the PGx information for the medications commonly encountered in  ...[more]

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