Systematic identification of mutations and copy number alterations associated with cancer patient prognosis.
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ABSTRACT:
SUBMITTER: Smith JC
PROVIDER: S-EPMC6289580 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Systematic identification of mutations and copy number alterations associated with cancer patient prognosis.
Smith Joan C JC Sheltzer Jason M JM
eLife 20181211
Successful treatment decisions in cancer depend on the accurate assessment of patient risk. To improve our understanding of the molecular alterations that underlie deadly malignancies, we analyzed the genomic profiles of 17,879 tumors from patients with known outcomes. We find that mutations in almost all cancer driver genes contain remarkably little information on patient prognosis. However, CNAs in these same driver genes harbor significant prognostic power. Focal CNAs are associated with wors ...[more]
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