Optimized Diffusion-Weighting Gradient Waveform Design (ODGD) formulation for motion compensation and concomitant gradient nulling.

ABSTRACT:

Purpose

To present a novel Optimized Diffusion-weighting Gradient waveform Design (ODGD) method for the design of minimum echo time (TE), bulk motion-compensated, and concomitant gradient (CG)-nulling waveforms for diffusion MRI.

Methods

ODGD motion-compensated waveforms were designed for various moment-nullings M_n (n = 0, 1, 2), for a range of b-values, and spatial resolutions, both without (ODGD-M_n ) and with CG-nulling (ODGD-M_n -CG). Phantom and in-vivo (brain and liver) experiments were conducted with various ODGD waveforms to compare motion robustness, signal-to-noise ratio (SNR), and apparent diffusion coefficient (ADC) maps with state-of-the-art waveforms.

Results

ODGD-M_n and ODGD-M_n -CG waveforms reduced t

SUBMITTER: Pena-Nogales O 

PROVIDER: S-EPMC6289642 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature