The early natural history of albuminuria in young adults with youth-onset type 1 and type 2 diabetes.

ABSTRACT:

Aims

To determine among adolescents and young adults with youth-onset type 1 diabetes and type 2 diabetes the rates and risk factors for albuminuria regression and progression.

Methods

Data from SEARCH, a longitudinal observational study of youth-onset type 1 diabetes (N = 1316) and type 2 diabetes (N = 143) were analyzed. Urine albumin:creatinine ratio (UACR) was measured from random urine specimens at baseline and follow-up visits (mean 7 years later). Albuminuria regression was defined as halving of baseline UACR when baseline UACR was ≥30 μg/mg; progression was defined as doubling of baseline UACR when follow-up UACR was ≥30 μg/mg, respectively. Multivariable regression assessed risk factors associated with low-risk albuminuria category (combined persistently-low albumin

SUBMITTER: Kahkoska AR 

PROVIDER: S-EPMC6289668 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature