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Wideband myocardial perfusion pulse sequence for imaging patients with a cardiac implantable electronic device.

ABSTRACT: PURPOSE:To develop a wideband cardiac perfusion pulse sequence and test whether it is capable of suppressing image artifacts in patients with a cardiac implantable electronic device (CIED), while not exceeding the specific absorption rate (SAR) limit (2.0 W/kg). METHODS:A wideband perfusion pulse sequence was developed by incorporating a wideband saturation pulse to achieve a good balance between saturation of magnetization and SAR. Clinical standard and wideband perfusion MRI scans were performed back-to-back in a randomized order on 16 patients with a CIED undergoing clinical cardiac MRI. Two expert readers graded the artifact intensity and extent on a segmental basis using a 5-point Likert scale, where significant artifact was defined by a composite score. The variance in myocardial signal prior to tissue-enhancement was analyzed to quantify artifact-intensity. Whole-body SAR values computed by the MR scanner were read from the DICOM header. Either a paired t-test or Wilcoxon signed-rank test was performed to compare two groups. RESULTS:While the mean whole-body SAR for a single-slice wideband perfusion scan (0.38 ± 0.08W/kg) was significantly (p < 0.05) higher than for a single-slice standard perfusion scan (0.11 ± 0.03W/kg), it was 81% below 2.0 W/kg. The mean variance in myocardial signal prior to tissue-enhancement was significantly (p < 0.001) higher for standard (422.6 ± 306.6 a.u.) than wideband (107.0 ± 60.9 a.u.). Among 105 myocardial segments, standard produced 19 segments (18%) that were deemed to have significant artifacts, whereas wideband produced only 3 segments (3%). CONCLUSION:A wideband perfusion pulse sequence is capable of suppressing image artifacts induced by a CIED while not exceeding SAR at 2.0 W/kg.

SUBMITTER: Hong K

PROVIDER: S-EPMC6289847 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Wideband myocardial perfusion pulse sequence for imaging patients with a cardiac implantable electronic device.

Hong KyungPyo K Collins Jeremy D JD Knight Bradley P BP Carr James C JC Lee Daniel C DC Kim Daniel D

Magnetic resonance in medicine 20180909 2

<h4>Purpose</h4>To develop a wideband cardiac perfusion pulse sequence and test whether it is capable of suppressing image artifacts in patients with a cardiac implantable electronic device (CIED), while not exceeding the specific absorption rate (SAR) limit (2.0 W/kg).<h4>Methods</h4>A wideband perfusion pulse sequence was developed by incorporating a wideband saturation pulse to achieve a good balance between saturation of magnetization and SAR. Clinical standard and wideband perfusion MRI sca ...[more]

PMID: 30229560

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Project description:PurposeTo develop an accelerated wideband cardiac perfusion pulse sequence and test whether it can produce diagnostically acceptable image quality and whether it can be used to reliably quantify myocardial blood flow (MBF) in patients with a cardiac implantable electronic device (CIED).Materials and methodsA fivefold-accelerated wideband perfusion pulse sequence was developed using compressed sensing to sample one arterial input function plane and three myocardial perfusion (MP) planes per heartbeat in patients with a CIED with heart rates as high as 102 beats per minute. Resting perfusion scans were performed in 10 patients with a CIED and in 10 patients with no device as a control group. Two clinical readers compared the resulting images and retrospective images of the 10 patients with a CIED, which were obtained by using a previously described twofold-accelerated wideband perfusion pulse sequence with temporal generalized autocalibrating partially parallel acquisition. Summed visual score (SVS) was defined as the sum of conspicuity, artifact, and noise scores individually ranging from 1 (worst) to 5 (best). Resting MBF in the remote zones was quantified using Fermi deconvolution.ResultsMedian SVS was significantly different (P < .05) between the prospective and retrospective CIED groups (13 vs nine) and between the nondevice group and the retrospective CIED group (13.5 vs nine); all median SVSs were nine or greater (clinically acceptable cut point). The median resting MBF in remote zones was not significantly different (P = .27) between patients with a CIED (1.1 mL/min/g; median left ventricular ejection fraction [LVEF], 52.5%) and patients with no device (1.3 mL/min/g; median LVEF, 64.0%). Mean MBF values were consistent with those (mean resting MBF range, 1.0-1.2 mL/min/g) reported by two prior state-of-the-art cardiac perfusion MRI studies.ConclusionThe proposed scan yielded diagnostically acceptable image quality and enabled reliable quantification of MBF with three MP planes per heartbeat in patients with a CIED with heart rates as high as 102 beats per minute. Supplemental material is available for this article. © RSNA, 2020.

Dataset Information

Wideband myocardial perfusion pulse sequence for imaging patients with a cardiac implantable electronic device.

Publications

Wideband myocardial perfusion pulse sequence for imaging patients with a cardiac implantable electronic device.

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