Ontology highlight
ABSTRACT:
SUBMITTER: Sakamoto T
PROVIDER: S-EPMC6290004 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Nature communications 20181211 1
High levels of boron (B) induce DNA double-strand breaks (DSBs) in eukaryotes, including plants. Here we show a molecular pathway of high B-induced DSBs by characterizing Arabidopsis thaliana hypersensitive to excess boron mutants. Molecular analysis of the mutants revealed that degradation of a SWItch/Sucrose Non-Fermentable subunit, BRAHMA (BRM), by a 26S proteasome (26SP) with specific subunits is a key process for ameliorating high-B-induced DSBs. We also found that high-B treatment induces ...[more]