Ontology highlight
ABSTRACT:
SUBMITTER: Percin GI
PROVIDER: S-EPMC6290072 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Percin Gulce Itir GI Eitler Jiri J Kranz Andrea A Fu Jun J Pollard Jeffrey W JW Naumann Ronald R Waskow Claudia C
Nature communications 20181211 1
Regulatory mechanisms controlling the pool size of spleen dendritic cells (DC) remain incompletely understood. DCs are continuously replenished from hematopoietic stem cells, and FLT3-mediated signals cell-intrinsically regulate homeostatic expansion of spleen DCs. Here we show that combining FLT3 and CSF1R-deficiencies results in specific and complete abrogation of spleen DCs in vivo. Spatiotemporally controlled CSF1R depletion reveals a cell-extrinsic and non-hematopoietic mechanism for DC poo ...[more]