Ontology highlight
ABSTRACT:
SUBMITTER: Wenk C
PROVIDER: S-EPMC6290099 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Wenk Catharina C Garz Anne-Kathrin AK Grath Sonja S Huberle Christina C Witham Denis D Weickert Marie M Malinverni Roberto R Niggemeyer Julia J Kyncl Michèle M Hecker Judith J Pagel Charlotta C Mulholland Christopher B CB Müller-Thomas Catharina C Leonhardt Heinrich H Bassermann Florian F Oostendorp Robert A J RAJ Metzeler Klaus H KH Buschbeck Marcus M Götze Katharina S KS
Blood advances 20181201 23
Mesenchymal stromal cells (MSCs) are crucial components of the bone marrow (BM) microenvironment essential for regulating self-renewal, survival, and differentiation of hematopoietic stem/progenitor cells (HSPCs) in the stem cell niche. MSCs are functionally altered in myelodysplastic syndromes (MDS) and exhibit an altered methylome compared with MSCs from healthy controls, thus contributing to disease progression. To determine whether MSCs are amenable to epigenetic therapy and if this affects ...[more]