Ontology highlight
ABSTRACT:
SUBMITTER: Waldt N
PROVIDER: S-EPMC6290345 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Waldt Natalie N Seifert Anke A Demiray Yunus Emre YE Devroe Eric E Turk Benjamin E BE Reichardt Peter P Mix Charlie C Reinhold Annegret A Freund Christian C Müller Andreas J AJ Schraven Burkhart B Stork Oliver O Kliche Stefanie S
Frontiers in immunology 20181204
The integrin LFA-1 (CD11a/CD18) plays a critical role in the interaction of T cells with antigen presenting cells (APCs) to promote lymphocyte differentiation and proliferation. This integrin can be present either in a closed or in an open active conformation and its activation upon T-cell receptor (TCR) stimulation is a critical step to allow interaction with APCs. In this study we demonstrate that the serine/threonine kinase Ndr2 is critically involved in the initiation of TCR-mediated LFA-1 a ...[more]