Ontology highlight
ABSTRACT:
SUBMITTER: Lorch Y
PROVIDER: S-EPMC6290470 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Lorch Yahli Y Maier-Davis Barbara B Kornberg Roger D RD
Molecular cell 20181025 3
The +1 nucleosome of yeast genes, within which reside transcription start sites, is characterized by histone acetylation, by the displacement of an H2A-H2B dimer, and by a persistent association with the RSC chromatin-remodeling complex. Here we demonstrate the interrelationship of these characteristics and the conversion of a nucleosome to the +1 state in vitro. Contrary to expectation, acetylation performs an inhibitory role, preventing the removal of a nucleosome by RSC. Inhibition is due to ...[more]