Variants in immune-related genes and genital HPV 16 persistence in men.

ABSTRACT: OBJECTIVES:While most human papillomavirus (HPV) infection clears on its own, persistent HPV infection can cause genital warts and anal, penile and oropharyngeal cancers in men. We conducted genetic analysis in a sub-cohort of the HPV infection in men (HIM) study to test the hypothesis that differences in host genes influence HPV persistence in men. METHODS:Baseline and longitudinal genital HPV status at the genitals was measured every 6-months using the Linear Array assay amplified HPV L1 gene fragment using the PGMY09/11 L1 consensus primer system. DNA was extracted from peripheral blood and single nucleotide polymorphisms (SNPs) in the customized genome-wide genotyping array, the "TxArray," were examined using logistic regression in a case-control study design to assess the association with HPV16 persistence/clearance. RESULTS:Of the total of 737,742 autosomal SNPs in the array, 605,885 passed basic quality control and were examined between 40 men (cases) with >?18 months persistent genital HPV 16 infection vs. 151 controls who were HPV 16-positive, but whose infections cleared in

SUBMITTER: Mainali B 

PROVIDER: S-EPMC6290760 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature