Unknown

Dataset Information

0

Light-driven fine chemical production in yeast biohybrids.


ABSTRACT: Inorganic-biological hybrid systems have potential to be sustainable, efficient, and versatile chemical synthesis platforms by integrating the light-harvesting properties of semiconductors with the synthetic potential of biological cells. We have developed a modular bioinorganic hybrid platform that consists of highly efficient light-harvesting indium phosphide nanoparticles and genetically engineered Saccharomyces cerevisiae, a workhorse microorganism in biomanufacturing. The yeast harvests photogenerated electrons from the illuminated nanoparticles and uses them for the cytosolic regeneration of redox cofactors. This process enables the decoupling of biosynthesis and cofactor regeneration, facilitating a carbon- and energy-efficient production of the metabolite shikimic acid, a common precursor for several drugs and fine chemicals. Our work provides a platform for the rational design of biohybrids for efficient biomanufacturing processes with higher complexity and functionality.

SUBMITTER: Guo J 

PROVIDER: S-EPMC6290997 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Light-driven fine chemical production in yeast biohybrids.

Guo Junling J   Suástegui Miguel M   Sakimoto Kelsey K KK   Moody Vanessa M VM   Xiao Gao G   Nocera Daniel G DG   Joshi Neel S NS  

Science (New York, N.Y.) 20181101 6416


Inorganic-biological hybrid systems have potential to be sustainable, efficient, and versatile chemical synthesis platforms by integrating the light-harvesting properties of semiconductors with the synthetic potential of biological cells. We have developed a modular bioinorganic hybrid platform that consists of highly efficient light-harvesting indium phosphide nanoparticles and genetically engineered <i>Saccharomyces cerevisiae</i>, a workhorse microorganism in biomanufacturing. The yeast harve  ...[more]

Similar Datasets

| S-EPMC2628649 | biostudies-literature
| S-EPMC6780262 | biostudies-literature
| S-EPMC7210317 | biostudies-literature
| S-EPMC6178918 | biostudies-literature
| S-EPMC4993189 | biostudies-literature
| S-EPMC10220010 | biostudies-literature
| PRJNA664624 | ENA
| PRJDB15117 | ENA
| S-EPMC10763269 | biostudies-literature
| S-EPMC5821488 | biostudies-literature