Ontology highlight
ABSTRACT:
SUBMITTER: Tiono AB
PROVIDER: S-EPMC6291132 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Tiono Alfred B AB Nébié Issa I Anagnostou Nicholas N Coulibaly Aboubacar S AS Bowyer Georgina G Lam Erika E Bougouma Edith C EC Ouedraogo Alphonse A Yaro Jean Baptist B JBB Barry Aïssata A Roberts Rachel R Rampling Tommy T Bliss Carly C Hodgson Susanne S Lawrie Alison A Ouedraogo Amidou A Imoukhuede Egeruan Babatunde EB Ewer Katie J KJ Viebig Nicola K NK Diarra Amidou A Leroy Odile O Bejon Philip P Hill Adrian V S AVS Sirima Sodiomon B SB
PloS one 20181212 12
<h4>Background</h4>Heterologous prime boost immunization with chimpanzee adenovirus 63 (ChAd63) and Modified Vaccinia Virus Ankara (MVA) vectored vaccines is a strategy previously shown to provide substantial protective efficacy against P. falciparum infection in United Kingdom adult Phase IIa sporozoite challenge studies (approximately 20-25% sterile protection with similar numbers showing clear delay in time to patency), and greater point efficacy in a trial in Kenyan adults.<h4>Methodology</h ...[more]