Ontology highlight
ABSTRACT:
SUBMITTER: Rahimi MN
PROVIDER: S-EPMC6291811 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20171213 2
Herein, we describe the synthesis and structure-activity relationships of cyclic peptides designed to target heat shock protein 90 (Hsp90). Generating 19 compounds and evaluating their binding affinity reveals that increasing electrostatic interactions allows the compounds to bind more effectively with Hsp90 compared to the lead structure. Exchanging specific residues for lysine improves binding affinity for Hsp90, indicating some residues are not critical for interacting with the target, wherea ...[more]