Ontology highlight
ABSTRACT:
SUBMITTER: Huang X
PROVIDER: S-EPMC6291981 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Huang Xianbo X Xiao Feng F Li Yuan Y Qian Wenbin W Ding Wei W Ye Xiujin X
Journal of experimental & clinical cancer research : CR 20181212 1
Resistance to regulated cell death is one of the hallmarks of human cancers; it maintains cell survival and significantly limits the effectiveness of conventional drug therapy. Leukemia represents a class of hematologic malignancies that is characterized by dysregulation of cell death pathways and treatment-related resistance. As the majority of chemotherapeutic and targeted drugs kill leukemia cells by triggering apoptosis, the observed resistance indicates the need for novel therapeutic strate ...[more]