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Posterior HOX genes and HOTAIR expression in the proximal and distal colon cancer pathogenesis.


ABSTRACT: BACKGROUND:Increasing evidences showed that the location of the primary tumor on the right (proximal) or left (distal) side of the colon have a prognostic/predictive value for colon cancer patients. However, the understanding of the molecular mechanisms that contribute to the pathogenesis in different location of colon is still unclear. Probably an important role could be played by genes that control the spatial-temporal development of bodily structures, such as HOX genes. METHODS:The main purpose of this study was to analyze the expression of the paralogous 13 HOX genes and of the HOX regulating lncRNA HOTAIR in distal and proximal CRC cases. We have carried out a Tissue Micro Array with left and right CRC samples associated with all clinical-pathological parameters of patients. The expression of HOX genes was evaluated by immunohistochemistry and the staining of HOTAIR was performed by in situ hybridization using a specifically designed LNA probe. RESULTS:All paralogous 13 HOX genes and HOTAIR are silent in normal tissue and expressed in CRC samples. HOXB13, HOXC13 and HOTAIR showed a statistical association with lymph nodes metastasis (p value?=?0.003, p value?=?0.05, p value?=?0.04). HOXB13, HOXC13 and lncRNA HOTAIR are overexpressed in right CRCs samples (p value?

SUBMITTER: Tatangelo F 

PROVIDER: S-EPMC6292169 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Posterior HOX genes and HOTAIR expression in the proximal and distal colon cancer pathogenesis.

Tatangelo Fabiana F   Di Mauro Annabella A   Scognamiglio Giosuè G   Aquino Gabriella G   Lettiero Antonio A   Delrio Paolo P   Avallone Antonio A   Cantile Monica M   Botti Gerardo G  

Journal of translational medicine 20181212 1


<h4>Background</h4>Increasing evidences showed that the location of the primary tumor on the right (proximal) or left (distal) side of the colon have a prognostic/predictive value for colon cancer patients. However, the understanding of the molecular mechanisms that contribute to the pathogenesis in different location of colon is still unclear. Probably an important role could be played by genes that control the spatial-temporal development of bodily structures, such as HOX genes.<h4>Methods</h4  ...[more]

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