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An ecotoxicological view on neurotoxicity assessment.

ABSTRACT: The numbers of potential neurotoxicants in the environment are raising and pose a great risk for humans and the environment. Currently neurotoxicity assessment is mostly performed to predict and prevent harm to human populations. Despite all the efforts invested in the last years in developing novel in vitro or in silico test systems, in vivo tests with rodents are still the only accepted test for neurotoxicity risk assessment in Europe. Despite an increasing number of reports of species showing altered behaviour, neurotoxicity assessment for species in the environment is not required and therefore mostly not performed. Considering the increasing numbers of environmental contaminants with potential neurotoxic potential, eco-neurotoxicity should be also considered in risk assessment. In order to do so novel test systems are needed that can cope with species differences within ecosystems. In the field, online-biomonitoring systems using behavioural information could be used to detect neurotoxic effects and effect-directed analyses could be applied to identify the neurotoxicants causing the effect. Additionally, toxic pressure calculations in combination with mixture modelling could use environmental chemical monitoring data to predict adverse effects and prioritize pollutants for laboratory testing. Cheminformatics based on computational toxicological data from in vitro and in vivo studies could help to identify potential neurotoxicants. An array of in vitro assays covering different modes of action could be applied to screen compounds for neurotoxicity. The selection of in vitro assays could be guided by AOPs relevant for eco-neurotoxicity. In order to be able to perform risk assessment for eco-neurotoxicity, methods need to focus on the most sensitive species in an ecosystem. A test battery using species from different trophic levels might be the best approach. To implement eco-neurotoxicity assessment into European risk assessment, cheminformatics and in vitro screening tests could be used as first approach to identify eco-neurotoxic pollutants. In a second step, a small species test battery could be applied to assess the risks of ecosystems.

SUBMITTER: Legradi JB

PROVIDER: S-EPMC6292971 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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An ecotoxicological view on neurotoxicity assessment.

Legradi J B JB Di Paolo C C Kraak M H S MHS van der Geest H G HG Schymanski E L EL Williams A J AJ Dingemans M M L MML Massei R R Brack W W Cousin X X Begout M-L ML van der Oost R R Carion A A Suarez-Ulloa V V Silvestre F F Escher B I BI Engwall M M Nilén G G Keiter S H SH Pollet D D Waldmann P P Kienle C C Werner I I Haigis A-C AC Knapen D D Vergauwen L L Spehr M M Schulz W W Busch W W Leuthold D D Scholz S S Vom Berg C M CM Basu N N Murphy C A CA Lampert A A Kuckelkorn J J Grummt T T Hollert H H

Environmental sciences Europe 20181214 1

The numbers of potential neurotoxicants in the environment are raising and pose a great risk for humans and the environment. Currently neurotoxicity assessment is mostly performed to predict and prevent harm to human populations. Despite all the efforts invested in the last years in developing novel in vitro or in silico test systems, in vivo tests with rodents are still the only accepted test for neurotoxicity risk assessment in Europe. Despite an increasing number of reports of species showing ...[more]

PMID: 30595996

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Project description:There is growing interest in the environmental safety of ultraviolet (UV) filters found in cosmetic and personal care products (CPCPs). The CPCP industry is assessing appropriate environmental risk assessment (ERA) methods to conduct robust environmental safety assessments for these ingredients. Relevant and reliable data are needed for ERA, particularly when the assessment is supporting regulatory decision-making. In the present study, we apply a data evaluation approach to incorporate nonstandard toxicity data into the ERA process through an expanded range of reliability scores over commonly used approaches (e.g., Klimisch scores). The method employs an upfront screening followed by a data quality assessment based largely on the Criteria for Reporting and Evaluating Ecotoxicity Data (CRED) approach. The method was applied in a coral case study in which UV filter toxicity data was evaluated to identify data points potentially suitable for higher tier and/or regulatory ERA. This is an optimal case study because there are no standard coral toxicity test methods, and UV filter bans are being enacted based on findings reported in the current peer-reviewed data set. Eight studies comprising nine assays were identified; four of the assays did not pass the initial screening assessment. None of the remaining five assays received a high enough reliability score (Rn ) to be considered of decision-making quality (i.e., R1 or R2). Four assays were suitable for a preliminary ERA (i.e., R3 or R4), and one assay was not reliable (i.e., R6). These results highlight a need for higher quality coral toxicity studies, potentially through the development of standard test protocols, to generate reliable toxicity endpoints. These data can then be used for ERA to inform environmental protection and sustainability decision-making. Environ Toxicol Chem 2021;40:3441-3464. © 2021 Personal Care Products Council. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

Dataset Information

An ecotoxicological view on neurotoxicity assessment.

Publications

An ecotoxicological view on neurotoxicity assessment.

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