Ontology highlight
ABSTRACT:
SUBMITTER: Awatade NT
PROVIDER: S-EPMC6293199 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Awatade Nikhil T NT Wong Sharon L SL Hewson Chris K CK Fawcett Laura K LK Kicic Anthony A Jaffe Adam A Waters Shafagh A SA
Frontiers in pharmacology 20181207
Cystic fibrosis (CF) is an inherited disorder where individual disease etiology and response to therapeutic intervention is impacted by CF transmembrane regulator (CFTR) mutations and other genetic modifiers. CFTR regulates multiple mechanisms in a diverse range of epithelial tissues. In this Review, we consolidate the latest updates in the development of primary epithelial cellular model systems relevant for CF. We discuss conventional two-dimensional (2-D) airway epithelial cell cultures, the ...[more]