Ontology highlight
ABSTRACT:
SUBMITTER: Watnick RS
PROVIDER: S-EPMC6293990 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Watnick R S RS Rodriguez R K RK Wang S S Blois A L AL Rangarajan A A Ince T T Weinberg R A RA
Oncogene 20140811 22
Tumor-associated angiogenesis is postulated to be regulated by the balance between pro- and anti-angiogenic factors. We demonstrate here that the critical step in establishing the angiogenic capability of human tumor cells is the repression of a key secreted anti-angiogenic factor, thrombospondin-1 (Tsp-1). This repression is essential for tumor formation by mammary epithelial cells and kidney cells engineered to express SV40 early region proteins, hTERT, and H-RasV12. In transformed epithelial ...[more]