Ontology highlight
ABSTRACT:
SUBMITTER: Negoro R
PROVIDER: S-EPMC6294172 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Negoro Ryosuke R Takayama Kazuo K Kawai Kanae K Harada Kazuo K Sakurai Fuminori F Hirata Kazumasa K Mizuguchi Hiroyuki H
Stem cell reports 20181121 6
The small intestine plays an important role in the absorption and metabolism of oral drugs. In the current evaluation system, it is difficult to predict the precise absorption and metabolism of oral drugs. In this study, we generated small intestinal epithelial-like cells from human induced pluripotent stem cells (hiPS-SIECs), which could be applied to drug absorption and metabolism studies. The small intestinal epithelial-like cells were efficiently generated from human induced pluripotent stem ...[more]