Ontology highlight
ABSTRACT:
SUBMITTER: Park H
PROVIDER: S-EPMC6294255 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Park Heuijoon H Lad Sonali S Boland Kelsey K Johnson Kelly K Readio Nyssa N Jin Guangchun G Asfaha Samuel S Patterson Kelly S KS Singh Ashok A Yang Xiangdong X Londono Douglas D Singh Anupama A Trempus Carol C Gordon Derek D Wang Timothy C TC Morris Rebecca J RJ
Nature communications 20181213 1
We used allogeneic bone marrow transplantation (BMT) and a mouse multistage cutaneous carcinogenesis model to probe recruitment of bone marrow-derived epithelial cells (BMDECs) in skin tumors initiated with the carcinogen, dimethylbenz[a]anthracene (DMBA), and promoted with 12-O-tetradecanolyphorbol-13-acetate (TPA). BMDECs clustered in the lesional epithelium, expressed cytokeratins, proliferated, and stratified. We detected cytokeratin induction in plastic-adherent bone marrow cells (BMCs) cul ...[more]