Ontology highlight
ABSTRACT:
SUBMITTER: Grozdanov PN
PROVIDER: S-EPMC6294498 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Grozdanov Petar N PN Masoumzadeh Elahe E Latham Michael P MP MacDonald Clinton C CC
Nucleic acids research 20181201 22
Cleavage and polyadenylation (C/P) of mRNA is an important cellular process that promotes increased diversity of mRNA isoforms and could change their stability in different cell types. The cleavage stimulation factor (CstF) complex, part of the C/P machinery, binds to U- and GU-rich sequences located downstream from the cleavage site through its RNA-binding subunit, CstF-64. Less is known about the function of the other two subunits of CstF, CstF-77 and CstF-50. Here, we show that the carboxy-te ...[more]