Ontology highlight
ABSTRACT:
SUBMITTER: Full F
PROVIDER: S-EPMC6294671 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Full Florian F van Gent Michiel M Sparrer Konstantin M J KMJ Chiang Cindy C Zurenski Matthew A MA Scherer Myriam M Brockmeyer Norbert H NH Heinzerling Lucie L Stürzl Michael M Korn Klaus K Stamminger Thomas T Ensser Armin A Gack Michaela U MU
Nature microbiology 20181112 1
Tripartite motif (TRIM) proteins mediate antiviral host defences by either directly targeting viral components or modulating innate immune responses. Here we identify a mechanism of antiviral restriction in which a TRIM E3 ligase controls viral replication by regulating the structure of host cell centrosomes and thereby nuclear lamina integrity. Through RNAi screening we identified several TRIM proteins, including TRIM43, that control the reactivation of Kaposi's sarcoma-associated herpesvirus. ...[more]