Ontology highlight
ABSTRACT: Objective
To assess the association between the outcome of a woman's first pregnancy and risk of clinical cardiovascular disease risk factors.Design
Prospective cohort study.Setting and population
Nurses' Health Study II.Methods
Multivariable-adjusted Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between first pregnancy outcome and hypertension, type 2 diabetes, and hypercholesterolemia.Main outcome measures
Hypertension, type 2 diabetes, and hypercholesterolemia.Results
Compared to women who reported a singleton live first birth, women with early spontaneous abortion (<12 weeks) had a greater rate of type 2 diabetes (HR: 1.20; 95% CI: 1.07-1.34) and hypercholesterolemia (HR: 1.06; 95% CI: 1.02-1.10), and a marginally increased rate of hypertension (HR: 1.05, 95% CI: 1.00-1.11). Late spontaneous abortion (12-19 weeks) was associated with an increased rate of type 2 diabetes (HR: 1.38; 95% CI: 1.14-1.65), hypercholesterolemia (HR: 1.11; 95% CI: 1.03-1.19), and hypertension (HR: 1.15; 95% CI: 1.05-1.25). The rates of type 2 diabetes (HR: 1.45; 95% CI: 1.13-1.87) and hypertension (HR: 1.15; 95% CI: 1.01-1.30) were higher in women who delivered stillbirth. In contrast, women whose first pregnancy ended in an induced abortion had lower rates of hypertension (HR: 0.87; 95% CI: 0.84-0.91) and type 2 diabetes (HR: 0.89; 95% CI: 0.79-0.99) than women with a singleton live birth.Conclusions
Several types of pregnancy loss were associated with an increased rate of hypertension, type 2 diabetes, and hypercholesterolemia, which may provide novel insight into the pathways through which pregnancy outcomes and CVD are linked.Tweetable abstract
Pregnancy loss is associated with later maternal risk of hypertension, type 2 diabetes, and hypercholesterolemia.
SUBMITTER: Horn J
PROVIDER: S-EPMC6294683 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Horn J J Tanz L J LJ Stuart J J JJ Markovitz A R AR Skurnik G G Rimm E B EB Missmer S A SA Rich-Edwards J W JW
BJOG : an international journal of obstetrics and gynaecology 20180923 1
<h4>Objective</h4>To assess the association between the outcome of a woman's first pregnancy and risk of clinical cardiovascular disease risk factors.<h4>Design</h4>Prospective cohort study.<h4>Setting and population</h4>Nurses' Health Study II.<h4>Methods</h4>Multivariable-adjusted Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between first pregnancy outcome and hypertension, type 2 diabetes, and hypercholesterol ...[more]