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Sex differences in long-term outcomes of patients across the spectrum of coronary artery disease.


ABSTRACT: BACKGROUND:Patients with nonobstructive coronary artery disease (CAD) have worse outcomes compared with those without CAD; however, few studies have compared the intermediate- and long-term impact of CAD severity as a function of patient sex. METHODS:We evaluated 5-year and long-term all-cause mortality of women and men undergoing elective coronary angiography at a single center by degree of CAD: no CAD (1%-24% stenosis), nonobstructive CAD (25%-69% epicardial stenosis or 25%-49% left main stenosis), or obstructive CAD (epicardial stenosis ?70% or left main stenosis ?50%), both overall and after adjusting for baseline clinical risk factors using Cox proportional-hazards models. RESULTS:Between January 1986 and July 2010, 8,766 women and 11,638 men underwent angiography and were followed for a median of 9.2?years. The majority (67%) of women had no CAD or nonobstructive CAD, whereas the majority of men had obstructive CAD (56%, P?

SUBMITTER: Pagidipati NJ 

PROVIDER: S-EPMC6294713 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Sex differences in long-term outcomes of patients across the spectrum of coronary artery disease.

Pagidipati Neha J NJ   Mudrick Daniel W DW   Chiswell Karen K   Brucker Amanda A   Peterson Eric D ED   Douglas Pamela S PS  

American heart journal 20181002


<h4>Background</h4>Patients with nonobstructive coronary artery disease (CAD) have worse outcomes compared with those without CAD; however, few studies have compared the intermediate- and long-term impact of CAD severity as a function of patient sex.<h4>Methods</h4>We evaluated 5-year and long-term all-cause mortality of women and men undergoing elective coronary angiography at a single center by degree of CAD: no CAD (1%-24% stenosis), nonobstructive CAD (25%-69% epicardial stenosis or 25%-49%  ...[more]

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