Ontology highlight
ABSTRACT:
SUBMITTER: Pedre B
PROVIDER: S-EPMC6294878 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Pedre Brandán B Young David D Charlier Daniel D Mourenza Álvaro Á Rosado Leonardo Astolfi LA Marcos-Pascual Laura L Wahni Khadija K Martens Edo E G de la Rubia Alfonso A Belousov Vsevolod V VV Mateos Luis M LM Messens Joris J
Proceedings of the National Academy of Sciences of the United States of America 20181121 50
Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) is a strong oxidant capable of oxidizing cysteinyl thiolates, yet only a few cysteine-containing proteins have exceptional reactivity toward H<sub>2</sub>O<sub>2</sub> One such example is the prokaryotic transcription factor OxyR, which controls the antioxidant response in bacteria, and which specifically and rapidly reduces H<sub>2</sub>O<sub>2</sub> In this study, we present crystallographic evidence for the H<sub>2</sub>O<sub>2</sub>-sensing mech ...[more]